| Ep | Date | Special Guest | Panel | Notes |
|---|---|---|---|---|
| 367 | January 6 | Dana Andrews | Bill, Betsy, Henry, Bess | |
| 368 | January 13 | No Guest | Bill, Betsy, Henry, Bess | |
| 369 | January 20 | Edmond O'Brien | Bill, Betsy, Henry, Bess | |
| 370 | January 27 | Jack E Leonard | Bill, Betsy, Henry, Bess | |
| 371 | February 3 | Jean-Pierre Aumont | Durward Kirby, Carol Burnett, Henry, Bess | Betsy Palmer hosts |
| 372 | February 10 | Steve Allen | Johnny Carson, Betsy, Henry, Bess | Ben Lyon (Host of I've Got a Secret in England) |
| 373 | February 17 | Peter Lorre | Bill, Betsy, Henry, Bess | |
| 374 | February 24 | Zsa Zsa Gabor | Bill, Betsy, Henry, Bess | Composer John Cale |
| 375 | March 2 | Anne Jeffreys & Robert Sterling | Bill, Betsy, Henry, Bess | |
| 376 | March 9 | Lloyd Bridges | Bill, Betsy, Henry, Florence Henderson | |
| 377 | March 16 | Olivia de Havilland | Bill, Betsy, Henry, Bess | |
| 378 | March 23 | Lawrence Harvey | Bill, Betsy, Henry, Bess | |
| 379 | March 30 | Janis Paige | Bill, Betsy, Henry, Bess | |
| 380 | April 6 | Mel Torme | Bill, Betsy, Henry, Bess | The Joe Mooney Quartet |
| 381 | April 13 | Julius La Rosa | Bill, Betsy, Henry, Bess | Frank De Vol |
| 382 | April 20 | Nancy Walker | Bill, Betsy, Henry, Bess | |
| 383 | April 27 | Art Linkletter | Bill, Betsy, Henry, Bess | |
| 384 | May 4 | Arthur Treacher | Durward Kirby, Betsy, Henry, Bess | Billy "Crash" Craddock |
| 385 | May 11 | Wally Cox | Durward Kirby, Betsy, Henry, Bess | |
| X | May 18 | NO SHOW | Playhouse 90: In the Presence of Mine Enemies | |
| 386 | May 25 | Burgess Meredith | Durward Kirby, Betsy, Henry, Bess | |
| 387 | June 1 | Jane Wyman | Bill, Florence Henderson, Henry, Bess | |
| 388 | June 8 | Tony Perkins | Bill, Betsy, Henry, Bess | |
| 389 | June 15 | Jay North | Bill, Betsy, Henry, Bess | |
| 390 | June 22 | Van Johnson | Bill, Betsy, Henry, Bess | Musician Jean-Jacques Perrey |
| 391 | June 29 | Victor Borge | Bill, Betsy, Henry, Bess | |
| 392 | July 6 | George Jessel | Bill, Betsy, Henry, Bess | Softball King Eddie Feigner |
| X | July 13 | NO SHOW | Democratic National Convention | |
| 393 | July 20 | Tony Randall | Bill, Betsy, Henry, Bess | |
| X | July 27 | NO SHOW | Republican National Convention | |
| 394 | August 3 | Johnny Carson | Durward Kirby, Betsy, Henry, Bess | |
| 395 | August 10 | Polly Bergen | Bill, Betsy, Henry, Bess | Panelist relatives Barra Grant, Ann Cullen, more |
| 396 | August 17 | Alan King | Bill, Betsy, Johnny Carson, Bess | |
| 397 | August 24 | Gloria Swanson | Bill, Betsy, Henry, Bess | |
| 398 | August 31 | Laraine Day | Bill, Betsy, Henry, Bess | Humorist Jean Shepherd |
| 399 | September 7 | Kids and Summer | Bill, Betsy, Henry, Bess | |
| 400 | September 14 | Vic Damone | Bill, Betsy, Henry, Bess | Wrestlers Shelby Wilson and Douglas Blubaugh |
| 401 | September 21 | Carol Burnett | Bill, Betsy, Henry, Bess | Musicians Bruce Haack and Ted Pandel |
| 402 | September 28 | Jonathan Winters | Bill, Betsy, Henry, Bess | Tommy Leach & Fred Parent (1903 World Series) |
| 403 | October 5 | Election Special | Bill, Betsy, Henry, Bess | Helen Hayes, Lauren Bacall, Tallulah Bankhead |
| 404 | October 12 | William Bendix | Bill, Betsy, Henry, Bess | |
| 405 | October 19 | Arlene Francis | Bill, Betsy, Henry, Bess | Bill Mazeroski |
| 406 | October 26 | John Payne | Bill, Betsy, Henry, Bess | |
| 407 | November 2 | Gisele MacKenzie | Bill, Betsy, Henry, Bess | Chimpanzee Kokomo Jr |
| 408 | November 9 | Audrey Meadows | Bill, Betsy, Henry, Bess | The Original Dixieland Jass Band |
| X | November 16 | NO SHOW | DuPont Show of the Month: Heaven Can Wait | |
| 409 | November 23 | Peter Ustinov | Bill, Betsy, Henry, Bess | Thanksgiving Show |
| 410 | November 30 | Myrna Loy | Bill, Betsy, Henry, Bess | Actress Annie Fargé |
| 411 | December 7 | Vivian Vance | Bill, Betsy, Henry, Bess | |
| 412 | December 14 | Eva Gabor | Bill, Jayne Meadows, Henry, Bess | Improvisational balladeer Steve DePass |
| 413 | December 21 | Faye Emerson | Bill, Carol Burnett, Henry, Bess | Christmas Show |
| 414 | December 28 | Celebrity Relatives | Bill, Carol Burnett, Henry, Bess |
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