| Ep | Date | Special Guest | Panel | Notes |
|---|---|---|---|---|
| 549 | January 6 | Jose Ferrer | Bill, Betsy, Henry, Bess | |
| 550 | January 13 | Carol Channing | Bill, Phyllis Diller, Henry, Bess | |
| 551 | January 20 | Arthur Godfrey | Bill, Rosemary Clooney, Henry, Bess | Salute to Radio with Brace Beemer, Quiz Kids |
| 552 | January 27 | Alan King | Bill, Betsy, Henry, Bess | |
| 553 | February 3 | Norman Paris | Bill, Betsy, Henry, Bess | |
| 554 | February 10 | Jonathan Winters | Bill, Betsy, Henry, Bess | |
| 555 | February 17 | Bobby Darin | Bill, Betsy, Henry, Bess | Tennis players Chuck McKinley, Dennis Ralston |
| 556 | February 24 | Morey Amsterdam | Bill, Betsy, Henry, Bess | |
| 557 | March 2 | Woody Allen | Bill, Betsy, Henry, Bess | |
| 558 | March 9 | Connie Stevens | Bill, Betsy, Henry, Bess | Betsy fills in when Connie gets sick. |
| 559 | March 16 | Art Carney | Bill, Betsy, Henry, Bess | Circus man Bill Ballantine |
| 560 | March 23 | E.G. Marshall | Bill, Betsy, Henry, Bess | |
| 561 | March 30 | Bette Davis | Bill, Betsy, Henry, Bess | Pete Best |
| 562 | April 6 | Wally Cox | Bill, Betsy, Henry, Bess | Colonel Harlan Sanders |
| 563 | April 13 | Suzy Parker | Bill, Betsy, Henry, Bess | |
| 564 | April 20 | Ed Begley | Allan Sherman, Betsy, Henry, Bess | Mathematician and author Edward O Thorp |
| 565 | April 27 | Olivia de Havilland | Louis Jordan, Betsy, Henry, Bess | Baseball's Ken Johnson |
| 566 | May 4 | Lloyd Bridges | Bill, Betsy, Henry, Bess | |
| 567 | May 11 | Durward Kirby | Bill, Betsy, Henry, Bess | |
| 568 | May 18 | Armed Forces Tribute | Bill, Betsy, Henry, Bess | Explorer Donald B MacMillan |
| 569 | May 25 | The Smothers Brothers | Bill, Betsy, Henry, Bess | |
| 570 | June 1 | Victor Borge | Bill, Betsy, Henry, Bess | |
| 571 | June 8 | Robert Merrill | Bill, Betsy, Henry, Bess | Olympic distance runner Buddy Edelen |
| 572 | June 15 | 12th Anniversary Show | Bill, Betsy, Henry, Bess | Staffers have Secrets |
| 573 | June 22 | Sam Levenson | Bill, Betsy, Henry, Bess | Olympic gymnasts Abie and Muriel Grossfeld |
| X | June 29 | RERUN | September 23, 1963 (E536) | |
| X | July 6 | RERUN | October 14, 1963 (E539) | |
| X | July 13 | NO SHOW | Republican National Convention | |
| X | July 20 | RERUN | November 11, 1963 (E543) | |
| X | July 27 | RERUN | December 2, 1963 (E545) | |
| X | August 3 | RERUN | February 17 (E555) | |
| X | August 10 | RERUN | December 9, 1963 (E546) | |
| X | August 17 | RERUN | March 30 (E561) | |
| X | August 24 | NO SHOW | Democratic National Convention | |
| X | August 31 | RERUN | October 21, 1963 (E540) | |
| X | September 7 | RERUN | May 11 (E567) | |
| 574 | September 14 | Milbourne Christopher | Betsy, Bill, Bess, Henry | Steve Allen becomes the new host. |
| 575 | September 21 | Edie Adams | Betsy, Bill, Bess, Henry | Chuck McCann |
| 576 | September 28 | Connie Francis | Betsy, Bill, Bess, Henry | Swimmer Leonore Modell |
| 577 | October 5 | Arlene Francis | Betsy, Bill, Bess, Henry | |
| 578 | October 12 | Carol Channing | Betsy, Bill, Bess, Henry | |
| 579 | October 19 | Julie Newmar | Betsy, Bill, Bess, Henry | |
| 580 | October 26 | Ray Walston | Betsy, Bill, Bess, Henry | Football's Timmy Brown |
| X | November 2 | NO SHOW | Paid political message | |
| 581 | November 9 | Victor Borge | Betsy, Bill, Bess, Henry | Football's Jim Marshall |
| 582 | November 16 | Robert Goulet | Betsy, Bill, Bess, Henry | The Shangri-Las |
| 583 | November 23 | Louis Nye | Betsy, Bill, Bess, Henry | |
| X | November 30 | NO SHOW | Leonard Bernstein Young People's Concert | |
| 584 | December 7 | Robert Merrill | Betsy, Bill, Bess, Henry | |
| 585 | December 14 | Steve Lawrence | Betsy, Bill, Bess, Henry | |
| 586 | December 21 | Christmas Show | Betsy, Bill, Bess, Henry | |
| 587 | December 28 | Durward Kirby | Betsy, Bill, Bess, Henry |
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