| Ep | Date | Special Guest | Panel | Notes |
|---|---|---|---|---|
| 630 | January 3 | Hugh O'Brien | Betsy, Bill, Bess, Henry | |
| 631 | January 10 | The King Sisters | Betsy, Bill, Bess, Henry | |
| 632 | January 17 | Celebrity Relatives | Betsy, Bill, Bess, Henry | |
| 633 | January 24 | Frank Gorshin | Betsy, Bill, Bess, Henry | |
| 634 | January 31 | Carol Burnett | Betsy, Bill, Bess, Henry | |
| 635 | February 7 | Robert Morse | Betsy, Bill, Bess, Henry | American hockey player Tom Williams |
| 636 | February 14 | Phyllis Diller | Betsy, Arthur Godfrey, Bess, Henry | Songwriter Harry Ruby |
| 637 | February 21 | John Daly | Betsy, Arthur Godfrey, Bess, Phyllis Diller | Boxer Henry Armstrong. Henry Morgan arrives late. |
| 638 | February 28 | Vivian Vance | Betsy, Bill, Jayne Meadows, Henry | |
| 639 | March 7 | Edgar Buchanan | Betsy, Bill, Lee Remick, Henry | |
| 640 | March 14 | TTTT Panel | Betsy, Bill, Bess, Henry | Tom Poston, Peggy Cass, Orson Bean, Kitty Carlisle |
| 641 | March 21 | Bob Holiday | Betsy, Bill, Bess, Henry | Inventor Hans Mauch |
| 642 | March 28 | Wilt Chamberlain | Jayne Meadows, Bill, Bess, Henry | |
| 643 | April 4 | Phil Ford & Mimi Hines | Jayne Meadows, Bill, Bess, Henry | Fashion designer Paco Rabanne |
| 644 | April 11 | George Segal | Betsy, Bill, Bess, Henry | |
| 645 | April 18 | Gretchen Wyler | Betsy, Bill, Bess, Henry | |
| 646 | April 25 | Joe Garagiola | Betsy, Bill, Bess, Henry | |
| 647 | May 2 | Sam Levenson | Betsy, Bill, Bess, Henry | |
| 648 | May 9 | E.G. Marshall | Betsy, Bill, Bess, Henry | |
| 649 | May 16 | Sheila MacRae | Betsy, Bill, Bess, Henry | |
| 650 | May 23 | Hugh O'Brien | Betsy, Bill, Bess, Henry | |
| 651 | May 30 | Shelley Winters | Betsy, Bill, Bess, Henry | Jazz musicians Sol Yaged, Terry Gibbs |
| 652 | June 6 | Arlene Francis | Betsy, Bill, Bess, Henry | |
| 653 | June 13 | Robert Goulet | Betsy, Bill, Bess, Henry | Fast Draw Pistol Champions Bob and Merrill Graham |
| 654 | June 20 | Sam Levenson | Betsy, Bill, Bess, Henry | Arthur Godfrey, Senator Milward Simpson |
| X | June 27 | RERUN | ||
| X | July 4 | RERUN | ||
| X | July 11 | RERUN | ||
| X | July 18 | RERUN | ||
| X | July 25 | RERUN | ||
| X | August 1 | RERUN | ||
| X | August 8 | RERUN | ||
| X | August 15 | RERUN | ||
| X | August 22 | RERUN | ||
| X | August 29 | RERUN | ||
| 655 | September 5 | Garry Moore | Betsy, Bill, Bess, Henry | Pool player Jean Balukas |
| 656 | September 12 | Arthur Godfrey | Betsy, Bill, Bess, Henry | Series moves to Mondays at 10:30pm and is now in color. |
| 657 | September 19 | Edie Adams | Betsy, Bill, Bess, Henry | |
| 658 | September 26 | Soupy Sales | Betsy, Bill, Bess, Henry | |
| 659 | October 3 | Buddy Hackett | Betsy, Bill, Bess, Henry | |
| 660 | October 10 | John Gary | Betsy, Bill, Bess, Henry | |
| 661 | October 17 | Lucille Ball | Betsy, Bill, Bess, Henry | Jazz musician Rufus Harley |
| 662 | October 24 | Jack E Leonard | Betsy, Bill, Bess, Henry | |
| X | October 31 | NO SHOW | NFL Football | |
| 663 | November 7 | Walter Cronkite | Betsy, Bill, Bess, Henry | |
| 664 | November 14 | Arlene Dahl | Betsy, Bill, Bess, Henry | Football placekicker Bert Rechichar |
| 665 | November 21 | Rossano Brazzi | Betsy, Bill, Bess, Henry | Congressman Kenneth J Grey |
| 666 | November 28 | Walter Pidgeon | Betsy, Bill, Bess, Henry | |
| 667 | December 5 | Bud Collyer | Betsy, Bill, Bess, Henry | The "Kit Kat Band" from Broadway's Cabaret |
| 668 | December 12 | Victor Borge | Betsy, Bill, Bess, Henry | Musicians Bruce Haack, Ted Pandel |
| 669 | December 19 | Christmas Show | Betsy, Bill, Bess, Henry | Pianists The Marlowe Brothers |
| 670 | December 26 | Paul Anka | Betsy, Bill, Bess, Henry | Sahara Acrobatic Troupe |
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